Exhaled isopropanol: new potential biomarker in diabetic breathomics and its metabolic correlations with acetone

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Exhaled isopropanol: new potential biomarker in diabetic breathomics and its metabolic correlations with acetone

Concomitant findings of acetone (ACE) and isopropanol (IPA) in blood and other biological samples have been reported in diabetic decedents and clinic cases, but exhaled IPA has rarely been studied in breath research. This study aimed to investigate expression of exhaled IPA in diabetes and further explore the correlations between exhaled IPA and ACE, and to evaluate diabetes diagnostic applicab...

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In heart failure patients, exhaled acetone concentration, a noninvasive biomarker, is increased according to heart failure severity. Moreover, exhaled acetone concentration is also known to be affected by diabetes mellitus. However, there have been no reports on exhaled acetone concentration in heart failure patients with diabetes mellitus. A 77-year old man was admitted to our hospital with ac...

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Development of a physiologically based pharmacokinetic model of isopropanol and its metabolite acetone.

A physiologically based pharmacokinetic (PBPK) model for isopropanol (IPA) and its major metabolite, acetone, is described. The structure of the parent chemical model, which can be used for either IPA or acetone by choosing the appropriate chemical-specific parameters, is similar to previously published models of volatile organic chemicals such as styrene. However, in order to properly simulate...

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Experiences with Volatile Alcoholism Indicators (Methanol, Acetone, Isopropanol) in DWI Car Drivers

State markers of alcoholism can be divided into (1) the indicators connected directly to ethanol metabolism and the substances involved in or by ethanol metabolism, and (2) the indicators that are not associated with actual blood alcohol concentrations, such as GGT, CDT, or MCV. Methanol, acetone, and isopropanol belong to the first group. These substances were detected and proposed as alcoholi...

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ژورنال

عنوان ژورنال: RSC Advances

سال: 2017

ISSN: 2046-2069

DOI: 10.1039/c7ra00815e